Gregory K. Pike

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1. A putative function of the transient outward current (ITO) in cardiac myocytes is to modulate the shape of the action potential and, consequently, cardiac contractility. In addition, it has been suggested that this current may help protect against arrhythmias during periods of cardiac ischaemia. In our investigation of the possible anti-arrhythmic action(More)
The local anaesthetics, tetracaine and procaine have previously been found to block, induce or potentiate Ca2+ release from the sarcoplasmic reticulum (SR) of skeletal muscle depending on the preparation, experimental conditions and design. We now show that low concentrations of tetracaine and procaine block SR Ca2+ release whereas high concentrations(More)
1. By analogy with studies on sarcoplasmic reticulum (SR) vesicles, Ca2+ release induced by heavy metals and mercaptans (e.g. cysteine) was investigated in rabbit skinned psoas fibres through measurements of isometric tension. 2. Heavy metals (at 2-5 microM) elicited phasic contractions by triggering Ca2+ release from the SR and had the following order of(More)
In isolated cervical segments of rat vagus nerve, over the temperature range 5-45 degrees C, reversible depolarizations to 5-hydroxytryptamine (5-HT) were maximal at 10 degrees C and negligible at 45 degrees C. Dose-response curves for this depolarization were compared at 20 degrees C and 37 degrees C, with a similar sensitivity but marked proportionate(More)
Axons of the rat isolated cervical vagus nerve responded to gamma-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT) with a readily reversible dose-dependent depolarization. Prior application of 5-HT at 2 or 30 microM equally depressed the depolarizing responses to GABA, shifting the GABA dose-response curve to the right and depressing the maximum; by(More)
Functional characterization of membrane channels by patch clamp techniques has revealed great diversity of transmitter or Voltage gated channels in native membranes. Concomitantly recombinant DNA techniques revealed a plethora of genes encoding channel subunits. Thus functional diversity within a particular class of channels may be generated by families of(More)
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