Gregory Jacobs

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Cutaneous leishmaniasis (CL) is one of the most important causes of chronic ulcerative skin lesions. The disease is endemic in many parts of the world, presenting a range of clinical forms - acute, chronic, recurrent and diffuse(1). Several species of Leishmania are involved, including L. major, L. tropica and L. aethiopica in the Old World, and several(More)
Topical treatment, with drug-containing ointments, of cutaneous leishmaniasis caused by Leishmania major in BALB/c mice was studied. Twenty chemotherapeutic agents having potential or established antileishmanial activity were formulated in different ointment and cream bases. Only 15% paromomycin sulfate with 12% methylbenzethonium chloride, 12% benzethonium(More)
Adaptations in aquatic invertebrate resting eggs that confer protection from natural catastrophic events also could confer protection from treatments applied to ballast water for biological invasion vector management. To evaluate the potential efficacy of physical ballast water treatment methods, the present study examined the acute toxicity of heat (flash(More)
OBJECTIVE To compare thoracic radiographs of clinically normal dogs and dogs with mild clinical heartworm disease with images transmitted by a desk-top, two-way audiovisual teleconferencing system. DESIGN Prospective, matched-set study. STUDY POPULATION 50 thoracic radiographs from clinically normal and heartworm-infected dogs and the digitally(More)
Several analogs of the glutathione (GSH) oxidizing reagent diamide [diazenedicarboxylic acid bis(N,N'-diethylamide)] were tested as radiosensitizers of aerobic cells. In general, radiosensitization correlates with the rate of reaction with cellular reducing agents and occurs only when the reductive capacity of the cell is exceeded. SR-4077,(More)
In Israel, the western shore of the Dead Sea, the Jordan Valley and the Aravah as well as the central Negev are considered endemic areas of cutaneous leishmaniasis. Every year hundreds of new cases are reported and in several villages 8 0 1 0 0 % of the local population is affected. All ages are susceptible to infection and many patients require treatment.(More)