Gregory J. Smith

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Naphthalene is a nasal carcinogen, inducing respiratory adenomas in male and olfactory neuroblastomas in female rats, respectively. The reasons for the site and sex-specific tumorigenic response are unknown. Naphthalene is bioactivated to electrophilic metabolites; cytotoxicity followed by regenerative cell proliferation is likely involved in the(More)
The target site for inhaled vapor-induced injury often differs in mouth-breathing humans compared with nose-breathing rats, thus complicating the use of rat inhalation toxicity data for assessment of human risk. We sought to examine sensitivity of respiratory/transitional nasal (RTM) and tracheobronchial (TBM) mucosa to two electrophilic irritant vapors:(More)
A designer looking at a drawing sometimes notices things not originally intended. Conversely, not all implications of a design action are considered before each depiction action is taken. This paper describes an approach to understanding and reproducing this behaviour based on a situated interaction with an external representation.
Mention of trade names or commercial products does not constitute endorsement or recommendation for use. requires the Administrator of the Environmental Protection Agency to publish water quality criteria that accurately reflect the latest scientific knowledge on the kind and extent of all identifiable effects on health and welfare that might be expected(More)
Informal notions of context often imply much more than that captured in many computational formalisms of it. The view presented in this paper, built on our understanding of designing, is of context being larger than any one agent's representation of it. This paper describes how for an agent's reasoning about context it is the current situation that(More)
Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit the sensation of irritation elicited by respiratory irritants. However, it remains unclear whether(More)
The terms " context " and " situation " are often used interchangeably or to denote a variety of concepts. This paper aims to show that these are two different but related concepts and it reifies their difference within the framework of design agents. The external world of an agent is described as the aggregation of all entities that the agent could(More)
Memory in a computational system is usually taken to be a place filled with things called " memories ". These places are indexed by either knowing its location or its content. For situated design agents, however, memory is a reflection of how the system has adapted to its environment. This paper describes the characteristics required of such a memory in a(More)