Gregory J. Smith

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Naphthalene is a nasal carcinogen, inducing respiratory adenomas in male and olfactory neuroblastomas in female rats, respectively. The reasons for the site and sex-specific tumorigenic response are unknown. Naphthalene is bioactivated to electrophilic metabolites; cytotoxicity followed by regenerative cell proliferation is likely involved in the(More)
Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit the sensation of irritation elicited by respiratory irritants. However, it remains unclear whether(More)
The target site for inhaled vapor-induced injury often differs in mouth-breathing humans compared with nose-breathing rats, thus complicating the use of rat inhalation toxicity data for assessment of human risk. We sought to examine sensitivity of respiratory/transitional nasal (RTM) and tracheobronchial (TBM) mucosa to two electrophilic irritant vapors:(More)
Design agents are rational agents that monitor and modify elements of a designed environment. Special characteristics of design agents include the ability to reason about patterns and concepts, and the ability to act autonomously in modifying or changing the design to achieve their own goals. 3D Virtual Worlds are multi-user distributed systems that provide(More)
Cystic fibrosis (CF) was one of the first inherited disorders for which gene therapy was seriously considered as a realistic option for treatment, and as such, it has long provided a paradigm for gene therapy of inherited diseases. However, despite the cloning of the cystic fibrosis transmembrane conductance regulator gene in 1989, over 15 years later a(More)
The terms “context” and “situation” are often used interchangeably or to denote a variety of concepts. This paper aims to show that these are two different but related concepts and it reifies their difference within the framework of design agents. The external world of an agent is described as the aggregation of all entities that the agent could possibly(More)
Aminoacyl-tRNA synthetases (ARSs) enhance the fidelity of protein synthesis through multiple mechanisms, including hydrolysis of the adenylate and cleavage of misacylated tRNA. Alanyl-tRNA synthetase (AlaRS) limits misacylation with glycine and serine by use of a dedicated editing domain, and a mutation in this activity has been genetically linked to a(More)
Cognitive studies of designers often involve sketching, but studies using artificial intelligence often apply a search paradigm. Sketching is an interaction between an agent and an environment. Perception influences how shape rules are applied, and the application of the rules influences future perception. One motivation behind our work is to(More)