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The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's disease. Magnetic resonance imaging (MRI), (18F)-fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, and cerebrospinal fluid (CSF) biomarkers, as well as(More)
High-quality prostate images were obtained with transceiver arrays at 7T after performing subject-dependent local transmit B(1) (B(1) (+)) shimming to minimize B(1) (+) losses resulting from destructive interferences. B(1) (+) shimming was performed by altering the input phase of individual RF channels based on relative B(1) (+) phase maps rapidly obtained(More)
UNLABELLED Immunohistochemical (IHC) assays performed on formalin-fixed paraffin-embedded (FFPE) tissue sections traditionally have been semi-quantified by pathologist visual scoring of staining. IHC is useful for validating biomarkers discovered through genomics methods as large clinical repositories of FFPE specimens support the construction of tissue(More)
Recent experimental data suggest that adiposity directly damages the heart by promoting ectopic deposition of triglyceride, a process known as myocardial steatosis. The goal of this study was to develop and validate proton magnetic resonance spectroscopy ((1)H MRS) as an in vivo tool to measure myocardial lipid content. Complementary studies in rat tissue(More)
This work reports preliminary results from the first human cardiac imaging at 7 Tesla (T). Images were acquired using an eight-channel transmission line (TEM) array together with local B(1) shimming. The TEM array consisted of anterior and posterior plates closely positioned to the subjects' thorax. The currents in the independent elements of these arrays(More)
Eight- and sixteen-channel transceive stripline/TEM body arrays were compared at 7 T (297 MHz) both in simulation and experiment. Despite previous demonstrations of similar arrays for use in body applications, a quantitative comparison of the two configurations has not been undertaken to date. Results were obtained on a male pelvis for assessing transmit,(More)
Molecular classification of diseases based on multigene expression signatures is increasingly used for diagnosis, prognosis, and prediction of response to therapy. Immunohistochemistry (IHC) is an optimal method for validating expression signatures obtained using high-throughput genomics techniques since IHC allows a pathologist to examine gene expression(More)
The purpose of this study was to detail a strategy for performing non-contrast enhanced renal magnetic resonance angiography studies at 7.0 T. It is demonstrated that with proper B1+ management, these studies can be successfully performed at ultrahigh field within local specific absorption rate constraints. An inversion prepared gradient echo acquisition,(More)
Three different coil configurations were evaluated through simulation and experimentally to determine safe operating limits and evaluate subject size-dependent performance for prostate imaging at 7 T. The coils included a transceiver endorectal coil (trERC), a 16-channel transceiver external surface array (trESA) and a trESA combined with a receive-only ERC(More)
Prognostic multibiomarker signatures in prostate cancer (PCa) may improve patient management and provide a bridge for developing novel therapeutics and imaging methods. Our objective was to evaluate the association between expression of 33 candidate protein biomarkers and time to biochemical failure (BF) after prostatectomy. PCa tissue microarrays were(More)