Gregory J. McRae

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Amyloid fibrillation has been intensively studied because of its association with various neurological disorders. While extensive time-dependent fibrillation experimental data are available and appear similar, few mechanistic models have been developed to unify those results. The aim of this work was to interpret these experimental results via a rigorous(More)
This paper presents the probabilistic collocation method as a computationally efficient method for performing uncertainty analysis on large complex models such as those used in global climate change research. The collocation method is explained, and then the results of its application to a box model of ocean thermohaline circulation are presented. A(More)
Short-term facilitation and depression refer to the increase and decrease of synaptic strength under repetitive stimuli within a timescale of milliseconds to seconds. This phenomenon has been attributed to primarily presynaptic mechanisms such as calcium-dependent transmitter release and presynaptic vesicle depletion. Previous modeling studies that aimed to(More)
Based on data from the 1997 Investigación sobre Materia Particulada y Deterioro Atmosférico-Aerosol and Visibility Evaluation Research (IMADA-EVER) campaign and the inorganic aerosol model ISORROPIA, the response of inorganic aerosols to changes in precursor concentrations was calculated. The aerosol behavior is dominated by the abundance of ammonia and(More)
Amyloid proteins are converted from their native-fold to long beta-sheet-rich fibrils in a typical sigmoidal time-dependent protein aggregation curve. This reaction process from monomer or dimer to oligomer to nuclei and then to fibrils is the subject of intense study. The main results of this work are based on the use of a well-studied model amyloid(More)
We have derived a parameterization consisting of a set of analytical expressions that approximate the predictions by the CIT Urban Airshed Model for the net export to the environment (i.e., effective emissions) of several chemical species, as functions of fourteen input parameters. For each species, effective emissions are a function of actual urban(More)
In the light of increasing fears about climate change, greenhouse gas mitigation technologies have assumed growing importance. In the United States, energy related CO2 emissions accounted for 98% of the total emissions in 2007 with electricity generation accounting for 40% of the total. Carbon capture and sequestration (CCS) is one of the options that can(More)
A kinetic model unifying presynaptic short-term facilitation and depression, " Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story(More)