Gregory J. McRae

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1. The contributions of alpha 2-adrenoceptors and 5-HT1A receptors to sexual behaviour in the rat have been re-evaluated by use of a highly potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197), yohimbine, idazoxan and the partial agonist at 5-HT1A receptors, 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT). 2. In a model where(More)
Short-term facilitation and depression refer to the increase and decrease of synaptic strength under repetitive stimuli within a timescale of milliseconds to seconds. This phenomenon has been attributed to primarily presynaptic mechanisms such as calcium-dependent transmitter release and presynaptic vesicle depletion. Previous modeling studies that aimed to(More)
A common viewpoint is that high performance computing offers the potential to revolutionize our approach to modern scientific and engineering practice. Unfortunately, in the debate about just how to realize the benefits much of the discussion is narrowly focused on just the hardware. What is missing is a more pragmatic assessment of how to reduce the(More)
There has been a massive expansion in the computational infrastructure supporting scientific research in the last five years. Today tens of thousands of researchers have access from their desktop computers to supercomputer centers over the national network. Scientific visualization has arisen as a critical tool of discovery, analysis and communication;(More)
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