Gregory J. Lewis

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BACKGROUND & AIMS Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the biologic relationship between the inflammatory bowel diseases. More than 30 CD susceptibility loci have been identified. These represent important candidate susceptibility loci for UC. Loci discovered by(More)
BACKGROUND NLRP3 (formerly known as CIAS1 or NALP3) encodes a key component of the inflammasome and is a strong candidate gene for Crohn's disease (CD) susceptibility. A recent study reported significant and internally replicated association between CD and six single nucleotide polymorphisms (SNPs) in a regulatory region 5.3 kb downstream of NLRP3.(More)
We have investigated the ternary mixture of complex hydrides with stoichiometry 2LiNH 2 + LiBH 4 + MgH 2 , and have identified a set of novel hydrogen storage reactions. One of these reactions involves the known reversible reaction Mg(NH 2) 2 + 2LiH ↔ Li 2 Mg(NH) 2 + 2H 2. Previous studies have shown that initiating this reaction from the binary mixture(More)
Conventional (e.g. MgH 2) and complex hydrides (e.g. ala-nates, borohydrides, and amides) are the two primary classes of solid-state hydrogen-storage materials. [1–3] Many of these " high-density " hydrides have the potential to store large amounts of hydrogen by weight (up to 18.5 wt % for LiBH 4) and/or volume (up to 112 g L À1 for MgH 2), values that are(More)
Here we apply combinatorial synthesis and screening (CSS) techniques with synthesis and testing of up to 48 samples in parallel to increase the rate of discovery of improved complex hydrides and dopants. In this paper we will demonstrate the application of CSS to a detailed investigation of the ternary LiNH 2 –MgH 2 –LiBH 4 phase diagram. Most points on(More)
A solid understanding of the molecular-level mechanisms responsible for zeolite crystallization remains one of the most challenging issues in modern zeolite science. Here we investigated the formation pathway for high-silica LTA zeolite crystals in the simultaneous presence of tetraethylammonium (TEA(+)), tetramethylammonium (TMA(+)), and Na(+) ions as(More)
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