Gregory J. Baker

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Glioblastoma multiforme (GBM) is the most common and deadliest of adult primary brain tumors. Due to its invasive nature and sensitive location, complete resection remains virtually impossible. The resistance of GBM against chemotherapy and radiotherapy necessitate the development of novel therapies. Gene therapy is proposed for the treatment of brain(More)
In human gliomas, the RTK/RAS/PI(3)K signaling pathway is nearly always altered. We present a model of experimental gliomagenesis that elucidates the contributions of genes involved in this pathway (PDGF-B ligand, HRAS-G12V, and AKT). We also examine the effect on gliomagenesis by the potential modifier gene, IDH1-R132H. Injections of lentiviral-encoded(More)
Sonobuoys equipped with a Global Positioning System (GPS) prove extremely useful when calibrating underwater sonar systems. Hermes Electronics Inc., in collaboration with Defence Research Establishment Atlantic (DREA) has developed such a buoy. The sonobuoy is a modified version of Hermes AN/SSQ53D(2) DIFAR sonobuoy. Modifications include de-sensitizing the(More)
Treatment of BRAF-mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use live-cell imaging, single-cell analysis, and molecular profiling to show that exposure of tumor cells to RAF/MEK inhibitors elicits a(More)
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