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Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor.

• Gregory Hamm, David Bonnel, +4 authors Jonathan Stauber
• Journal of proteomics
• 2012

In order to quantify small molecules at the early stage of drug discovery, we developed a quantitation approach based on mass spectrometry imaging (MSI) using matrix-assisted laser… (More)

Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator

• Satoshi Miyamoto, Cheng-Chih Hsu, +8 authors Kumar Sharma
• EBioMedicine
• 2016

AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high ATP/AMP ratio, however the quantitation of nucleotides in vivo has been extremely difficult. Via matrix-assisted… (More)

MALDI-TOF MS imaging of controlled release implants.

• Frauke Kreye, Gregory Hamm, +4 authors Juergen Siepmann
• Journal of controlled release : official journal…
• 2012

MALDI-TOF MS (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry) imaging is used to characterize novel lipid implants allowing for controlled drug delivery. Importantly,… (More)

Uncovering the regional localization of inhaled salmeterol retention in the lung

• Erica Bäckström, Gregory Hamm, +5 authors Markus Fridén
• Drug delivery
• 2018

Treatment of respiratory disease with a drug delivered via inhalation is generally held as being beneficial as it provides direct access to the lung target site with a minimum systemic exposure.… (More)

Microenvironment Tumor Metabolic Interactions Highlighted by qMSI: Application to the Tryptophan-Kynurenine Pathway in Immuno-Oncology.

• Rima Ait-Belkacem, Vanesa Bol, +6 authors Bruno Squárcio Fernandes Gomes
• SLAS discovery : advancing life sciences R & D
• 2017

Inhibition of NK and effector T-cell functions and activation of regulatory cell populations are the main immunosuppressive effects of indoleamine-2,3-dioxygenase1 (IDO1). By converting tryptophan… (More)

Abstract 17220: In Situ Multimodal Molecular Imaging and Staining Technologies Supporting Target Validation in Cardiovascular Disease

• Kim Holmstrøm, Gregory Hamm, +13 authors Jan H. N. Lindeman
• 2017

Abstract 16362: Adenosine Deaminase 2 Inhibits Adenosine-Driven Neutrophil Activation in Atherosclerosis

• Danielle van Keulen, Silvia Aldi, +11 authors Dennie Tempel
• 2017

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis

• Silvia Aldi, Ljubica Perisic Matic, +15 authors Eva Hurt-Camejo
• Molecular therapy. Methods & clinical development
• 2018

Variants in the PLPP3 gene encoding for lipid phosphate phosphohydrolase 3 have been associated with susceptibility to atherosclerosis independently of classical risk factors. PLPP3 inactivates… (More)

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