Gregory G. Scott

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While inhaled polycyclic aromatic hydrocarbons have long been suspected to induce lung cancer in humans, their dosimetry has not been fully elucidated. A key question is whether the critical exposure occurs during absorption in the lungs, or if toxicants in the systemic circulation contribute significantly to lung cancer risk. In particular, data are needed(More)
In pulmonary toxicity screening tests in which the epithelial lining fluid (ELF) is sampled by bronchoalveolar lavage (BAL), investigators have observed both increases and decreases in alkaline phosphatase (AP) activity in BAL fluid during an acute inflammatory response. Such alterations in AP activity are difficult to interpret because of uncertainties(More)
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the world, and is often identified by the presence of subdural and/or subarachnoid hemorrhages that develop from ruptured cortical vessels during brain-skull displacement. The pia-arachnoid complex (PAC), also known as the leptomeninges, is the major mechanical connection(More)
Traumatic brain injury (TBI) is a leading cause of death and disability in the USA. To help understand and better predict TBI, researchers have developed complex finite element (FE) models of the head which incorporate many biological structures such as scalp, skull, meninges, brain (with gray/white matter differentiation), and vasculature. However, most(More)
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