Gregory Clyde Mitchell

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Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in(More)
A single nucleotide polymorphism (SNP) in the neuropeptide Y gene has been associated with elevated serum lipid levels and cardiovascular disease. The polymorphism (T1128C) changes the seventh amino acid in the prohormone from leucine to proline. It has been speculated this alters neuropeptide Y (NPY) synthesis, trafficking, or secretion. We tested this(More)
Radiotherapy for head and neck tumors often results in persistent loss of function in salivary glands. Patients suffering from impaired salivary function frequently terminate treatment prematurely because of reduced quality of life caused by malnutrition and other debilitating side-effects. It has been previously shown in mice expressing a constitutively(More)
Peyronie's disease is a localized connective tissue disease characterized by an active, inflammatory phase and a stable, quiescent phase, with the eventual development of collagenous plaques within the tunica albuginea of the penis. Risk factors primarily associated with Peyronie's disease include Dupuytren's contracture, penile trauma, and family history.(More)
The blood of beef cattle given single doses (1 milligram per kilogram of body weight) of diphenadione (2-diphenylacetyl-1,3-indandione) became toxic to vampire bats (Desmodus rotundus) and remained toxic for 3 days without harming the cattle. Cattle at three ranches in Mexico treated with single intraruminal injections of diphenadione experienced a(More)
The treatment of Peyronie's disease (PD) is a challenge for the clinician. In the quest to straighten the penis, alleviate pain, prevent further shortening, and restore erectile function, many non-surgical treatments have been offered in lieu of an operative approach, which is still considered the gold standard for definitive treatment. This communication(More)
INTRODUCTION The risk of sexual dysfunction due to bicycling has been addressed in the literature for both men and women. New studies have provided information about the prevalence, pathophysiology, and strategies for prevention of sexual dysfunction as it relates to cycling. AIM The aim of this article is to review the current literature about(More)
We read with interest the article by Porst et al. [1]. The authors demonstrate statistically significant improvement in International Prostate Symptom Score (IPSS) with 5 mg/d tadalafil treatment compared to placebo ( 5.6 vs 3.6; p = 0.004) inmenwith lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH; LUTS/ BPH). The authors(More)