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BACKGROUND Early switch to oral antibacterials is recommended for the treatment of hospitalized patients with community-acquired pneumonia (CAP). However, its efficacy and safety in patients with more severe forms of CAP have not been well established. OBJECTIVE To evaluate early switch to oral treatment in hospitalized patients with moderate to severe(More)
We evaluated the clinical evidence regarding probiotic use for the prevention of respiratory tract infections (RTIs). Randomised controlled trials (RCTs) studying the effects of probiotics for the prevention of upper or lower RTIs were systematically identified. Fourteen RCTs (twelve involving healthy subjects and two involving patients with RTIs) were(More)
Wear is a major late complication of total joint arthroplasty, particularly for younger, active patients. Many patients could produce > 40 million motion cycles after joint replacement. Based on current experience and testing, typical joint prostheses are likely to wear out, and need revision in such patients. One problem is degradation of the metal(More)
INTRODUCTION Statins are currently used for hyperlipidaemia control and considered useful for protection from cardiovascular events. In addition, there is increasing evidence for the potential use of statins in preventing and treating infections. METHODS We performed a systematic review of the literature that compared the outcome between statin and(More)
BACKGROUND The potential need for re-evaluation of guidelines on surgical antimicrobial prophylaxis (AMP) in an era of advancing antimicrobial resistance is a matter of a considerable controversy. METHOD Review of the pertinent literature. RESULTS Over the last decade, the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) has increased(More)
Significant wear-through and dissociation failures of metal-backed, point and line contact patellar replacements are associated with excessive contact stresses on the polyethylene-bearing surfaces. Analytical mathematical contact-stress analysis was used to evaluate various patellar component geometries under loading conditions consistent with walking,(More)
Bacterial interference refers to the antagonism between bacterial species during the process of surface colonisation and acquisition of nutrients. The clinical evidence on the potential applications of microorganisms for the prevention and/or treatment of infections in the upper respiratory, urogenital and gastrointestinal tracts was reviewed through the(More)
AIM To assess the utilisation of an interventional radiology day unit (RDU), the rates of on-time discharges, the financial performance of the unit, and finally, the patient satisfaction rates. MATERIALS AND METHODS Data regarding the unit utilisation, discharge times, and complications were retrospectively collected for the first 2 years of operation of(More)
BACKGROUND China is one of the most rapidly developing countries with a huge population spreading on a chaotic area. For centuries Chinese medicine was based on tradition, religion and experience. However, the last two decades under the pressure of globalization Chinese medicine is turning gradually to evidence-based medicine, contributing in international(More)