Gregory C. Clarke

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It is possible that the process of repeatedly measuring the smoking behaviour of adolescents may very well affect that behaviour. This paper reports a test for the extent of such a "Hawthorne" effect in a longitudinal survey of smoking by English adolescents. The self-reported smoking behaviour of 15-16 year olds who attended schools which had participated(More)
Human cells derived from both normal and neoplastic tissues can be infected by Mason-Pfizer monkey virus (MPMV) without accompanying cytopathology. Infection of cell cultures such as human rhabdomyosarcoma (A204) results in a persistenly infected cell line which can be subcultured over 30 sequential culture passages without significant change in phenotype(More)
Monoclonal antibodies were raised against the guinea pig line 10 (L10) hepatocarcinoma, and an IgG1-producing hybridoma (D3) was selected for further study. D3 is a true monoclonal antibody as demonstrated by two-dimensional gel electrophoresis. Radioimmunoassays on live cells revealed no cross-reactivity with normal tissues or with the line 1(More)
Monoclonal antibodies were raised against the guinea pig line 10 (L10) hepatocarcinoma, and an lgG1-producing hybridoma (D3) was selected for further study. D3 is a true monoclonal antibody as demonstrated by two-dimensional gel electrophoresis. Radioimmunoassays on live cells revealed no cross-reactivity with normal tissues or with the line 1(More)
The performance of a new turbine spirometer, which has several advantages over equipment previously used to measure lung function, was compared with that of a conventional spirometer (Vitalograph) in a cross-over trial on 368 children six to 11 years old. On average, slightly higher values of forced expiratory volume at 0.75 s and forced vital capacity were(More)
Monoclonal antibodies to tumor-associated antigens (TAA) of human colorectal cancer were elicited using immunosorbents of lectins combined with peripheral protein extracts of xenografted colon adenocarcinoma. This method of immunization was compared with whole cells from surgical specimens and to crude membranes from xenografted tumors. The immunosorbent(More)
In the winters of 1977-8 and 1978-9 about 400 children in seven junior schools in northern England were taught the "My Body" health education programme. In the springs of 1980 and of 1982 these children, and an age matched control group, answered a questionnaire about their smoking behaviour, knowledge, and attitudes. Comparison of the two groups suggested(More)