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Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

• Melanie Philipp, Gregory B. Fralish, +4 authors Marc G. Caron
• Molecular biology of the cell
• 2008

Smoothened, a heptahelical membrane protein, functions as the transducer of Hedgehog signaling. The kinases that modulate Smoothened have been thoroughly analyzed in flies. However, little is known… (More)

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

• Alison R Meloni, Gregory B. Fralish, +5 authors Marc G. Caron
• Molecular and cellular biology
• 2006

Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular… (More)

Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.

• Alyson M Wilbanks, Gregory B. Fralish, M. J. L. Kirby, Larry S Barak, Yinxiong Li, Marc G. Caron
• Science
• 2004

beta-arrestins are multifunctional proteins that act as scaffolds and transducers of intracellular signals from heptahelical transmembrane-spanning receptors (7TMR). Hedgehog (Hh) signaling, which… (More)

Cell-Free Synthesis of Pectin (Identification and Partial Characterization of Polygalacturonate 4-[alpha]-Galacturonosyltransferase and Its Products from Membrane Preparations of Tobacco…

• Ron Lou Doong, Karen A. Liljebjelke, Gregory B. Fralish, Arun Kumar, Debra Mohnen
• Plant physiology
• 1995

Polygalacturonate 4-[alpha]-galacturonosyltransferase (EC 2.4.1.43) activity has been identified in microsomal membranes isolated from tobacco (Nicotiana tabacum L. cv Samsun) cell-suspension… (More)

Grk5l controls heart development by limiting mTOR signaling during symmetry breaking.

• Martin D. Burkhalter, Gregory B. Fralish, Richard T Premont, Marc G. Caron, Melanie Philipp
• Cell reports
• 2013

The correct asymmetric placement of inner organs is termed situs solitus and is determined early during development. Failure in symmetry breaking results in conditions ranging from randomized organ… (More)

N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.

• Sebastien Nicolas Marion, Gregory B. Fralish, Stéphane A Laporte, Marc G. Caron, Larry S Barak
• The Journal of biological chemistry
• 2007

The highly homologous beta-arrestin1 and -2 adaptor proteins play important roles in the function of G protein-coupled receptors. Either beta-arrestin variant can function as a molecular chaperone… (More)

Consequences of single-chain translation on the structures of two chorionic gonadotropin yoked analogs in alpha-beta and beta-alpha configurations.

• Gregory B. Fralish, Prema Narayan, David Puett
• Molecular endocrinology
• 2003

Human chorionic gonadotropin (hCG) is a placental-derived heterodimeric glycoprotein hormone, which, through the binding and activation of the LH receptor, rescues the corpus luteum and maintains… (More)

Identification of conventional and novel endothelin receptors in sheep choroid plexus cells

• Krassimira Angelova, Gregory B. Fralish, David Puett, Prema Narayan
• Molecular and Cellular Biochemistry
• 1996

Previous studies have demonstrated the presence of super-high affinity endothelin receptors with apparent Kd's on the order of pM in different brain tissues. This study was designed to characterize,… (More)

High-level expression of a functional single-chain human chorionic gonadotropin-luteinizing hormone receptor ectodomain complex in insect cells.

• Gregory B. Fralish, Prema Narayan, David Puett
• Endocrinology
• 2001

Reproductive capacity in primates is dependent on the high-affinity binding of the glycoprotein hormones LH and human (h)CG to the large ectodomain (ECD) of their common receptor (LHR). Our… (More)

Structural analysis of yoked chorionic gonadotropin-luteinizing hormone receptor ectodomain complexes by circular dichroic spectroscopy.

• Gregory B. Fralish, Brian M. Dattilo, David Puett
• Molecular endocrinology
• 2003

Binding of the heterodimeric glycoprotein hormone, chorionic gonadotropin (CG), occurs to the heptahelical LH receptor N-terminal ectodomain (ECD), a large portion of which has been modeled as a… (More)

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