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Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.

• Ruth Perets, Gregory A. Wyant, +12 authors Ronny Drapkin
• Cancer cell
• 2013

High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site,… (More)

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.

• Shannon M McAuliffe, Stefanie L. Morgan, +17 authors Daniela M. Dinulescu
• Proceedings of the National Academy of Sciences…
• 2012

Chemoresistance to platinum therapy is a major obstacle that needs to be overcome in the treatment of ovarian cancer patients. The high rates and patterns of therapeutic failure seen in patients are… (More)

Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy.

• Ashish A Kulkarni, Bhaskar Roy, +11 authors Shiladitya Sengupta
• Cancer research
• 2013

The centrality of phosphoinositide-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intratumoral… (More)

“Take it up a NOTCH

• Stefanie L. Morgan, Gregory A. Wyant, Daniela M. Dinulescu
• Cell cycle
• 2013

Long-term survival of ovarian cancer patients is poor due to lack of early detection and high rates of therapeutic failure and chemoresistance. It is estimated that 15,500 women in the United States… (More)

Supramolecular nanoparticles that target phosphatidylinositol-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy

• Ashish A. Kulkarni, Bhaskar Roy, +12 authors Shiladitya Sengupta
• 2013

Ashish A. Kulkarni, Bhaskar Roy, Poornima S. Rao, Gregory A. Wyant, Ayaat Mahmoud, Madhumitha Ramachandran, Poulomi Sengupta, Aaron Goldman, Venkata Ramana Kotamraju, Sudipta Basu, Raghunath A… (More)

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