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FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, present in gene clusters can have a profound influence on the final yield(More)
BACKGROUND Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. Genes encoding erythromycin biosynthesis are organized in a gene cluster, spanning over 60 kbp of DNA. Most often, gene clusters encoding biosynthesis of secondary metabolites contain regulatory genes. In contrast, the erythromycin(More)
A comparison between weak form meshless local Petrov-Galerkin method (MLPG) and strong form meshless diffuse approximate method (DAM) is performed for the diffusion equation in two dimensions. The shape functions are in both methods obtained by moving least squares (MLS) approximation with the polynomial weight function of the fourth order on the local(More)
The performance of the parallel implementation of the local meshless numerical method in solving system of coupled partial differential equations is explored. Presented numerical approach makes the computation convenient for parallel implementation using OpenMP based parallelization. The numerical experiments are performed on the de Vahl Davis natural(More)
BACKGROUND Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-producing actinomycete Saccharopolyspora erythraea. Further(More)
Fretting is a phenomenon that occurs at the contacts of surfaces that are subjected to oscillatory relative movement of small amplitudes. Depending on service conditions, fretting may significantly reduce the service life of a component due to fretting fatigue. In this regard, the analysis of stresses at contact is of great importance for predicting the(More)