Gregg S. Pettis

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Streptomyces turgidiscabies Car8 is an actinobacterium that causes the economically important disease potato scab. Pathogenesis in this species is associated with a mobile pathogenicity island (PAISt) that site specifically inserts into the bacA gene in Streptomyces spp. Here we provide the 674,223 bp sequence of PAISt, which consists of two non-overlapping(More)
In a process known as phase variation, the marine bacterium and cholera pathogen Vibrio cholerae alternately expresses smooth or rugose colonial phenotypes, the latter being associated with advanced biofilm architecture and greater resistance to ecological stress. To define phase variation at the transcriptomic level in pandemic V. cholerae O1 El Tor strain(More)
Phase variation in the Gram-negative human pathogen Vibrio vulnificus involves three colonial morphotypes- smooth opaque colonies due to production of capsular polysaccharide (CPS), smooth translucent colonies as the result of little or no CPS expression, and rugose colonies due to production of a separate extracellular polysaccharide (EPS), which greatly(More)
ii ACKNOWLEDGMENTS I would like to express my sincere and deepest appreciation to my advisor, Dr. Donal F. Day for his advice, motivation and support as well as his encouragement and understanding throughout this work. who are my best friends in my life. Finally, I would like to dedicate this work to my wife, Kyung-Ran, our daughter, Lauren, my parents, and(More)
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