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  • Gregg L Semenza
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2003 (First Publication: 1 December 2003)
  • Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.Expand
  • Gregg L Semenza, Gexin Wang
  • Biology, Medicine
  • Molecular and cellular biology
  • 1992 (First Publication: 1 December 1992)
  • We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold transcriptional induction in response to hypoxia when cloned 3' to aExpand