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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
thus the discovery of a major new group of thesebacteria in marine sediments suggests that the ocean repre-sents an overlooked habitat from which to isolate theseimportant microorganisms. GivenExpand
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Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.
[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and BExpand
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Assignment of 1H and 13C spectra and investigation of hindered side‐chain rotation in lupeol derivatives †
Complete 1H and 13C spectral assignments are reported for lupeol (1a) and two derivatives where the C‐30 methyl group is replaced by CH2OH (1b) and HC O (1c). Compound 1c shows conformationallyExpand
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New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica.
An extensive study of the secondary metabolites produced by the obligate marine actinomycete Salinispora tropica (strain CNB-392), the producing microbe of the potent proteasome inhibitorExpand
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