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Changes in protein-protein interactions and activity states have been proposed to underlie persistent synaptic remodeling that is induced by transient stimuli. Here, we show an unusual stimulus-dependent transition from a short-lived to long-lasting binding between a synaptic receptor and its transducer. Both molecules, the NMDA receptor subunit NR2B and… (More)
The new ATM concepts proposed by both SESAR and Next Gen require a paradigm shift from an often uncoordinated system that relies on centralized, ground-based tactical separation assurance to an integrated and coordinated one centered on strategic, collaborative trajectory management. Thus, in the future European ATM system defined by SESAR, the aircraft… (More)
The influence of adult stem cells on tumor growth is paradoxical. On one hand, angiogenic factors secreted by stem cells are known to be essential for tumor vascularization. On the other hand, stem cell-derived factors can reportedly induce tumor differentiation or direct death of tumor cells. Both the placenta and umbilical cord are rich sources of stem… (More)
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In this paper the effect of different aircraft automated descent guidance strategies on fuel burn and the temporal predictability of the executed trajectory is investigated. The paper aims to provide an understanding of how airborne automation can be permitted by Air Traffic Control to remain in control of the descent in the presence of disturbances while… (More)
Accurate trajectory prediction is the cornerstone for future Air Traffic Management (ATM) concepts worldwide. To this purpose, researchers from Airservices Australia, the Federal Aviation Administration (FAA), and EUROCONTROL have collaborated on research into this important topic. Trajectory prediction is the process in which the future trajectory of an… (More)