Greg Martinka

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BACKGROUND Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant(More)
INTRODUCTION Data are sparse as to whether obesity influences the risk of death in critically ill patients with septic shock. We sought to examine the possible impact of obesity, as assessed by body mass index (BMI), on hospital mortality in septic shock patients. METHODS We performed a nested cohort study within a retrospective database of patients with(More)
INTRODUCTION The fact that acute kidney injury (AKI) is associated with worse clinical outcomes forms the basis of most AKI prognostic scoring systems. However, early reversibility of renal dysfunction in acute illness is not considered in such systems. We sought to determine whether early (≤24 hours after shock documentation) reversibility of AKI was(More)
OBJECTIVES To identify clinical and organizational factors associated with delays in antimicrobial therapy for septic shock. DESIGN In a retrospective cohort of critically ill patients with septic shock. SETTING Twenty-four ICUs. PATIENTS A total of 6,720 patients with septic shock. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Higher Acute(More)
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