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Medical imaging has opened a new door into biomedical research. In order to study various diseases of the brain and detect their impact on brain structure, robust and user friendly image processing packages are required. These packages must be multi-faceted to distinguish variations in size, shape, volume, and the ability to detect longitudinal changes over(More)
The University of Iowa's Psychiatric Iowa Neuroimaging Consortium (PINC) has developed a program for mutual information registration of BRAINS2 [2] data using ITK [1] classes, called BRAINSFit. We have written a helper class, itk::MultiModal3DMutualRegistrationHelper to simplify implementation and testing of different transform representations and(More)
Acinetobacter baumannii is an emerging bacterial pathogen that causes nosocomial pneumonia and other infections. Although it is recognized as an increasing threat to immunocompromised patients, the mechanism of host defense against A. baumannii infection remains poorly understood. In this study, we examined the potential role of macrophages in host defense(More)
Allergic asthma is a dysregulation of the immune system which leads to the development of Th2 responses to innocuous antigens (allergens). Some infections and microbial components can re-direct the immune response toward the Th1 response, or induce regulatory T cells to suppress the Th2 response, thereby inhibiting the development of allergic asthma. Since(More)
Acknowledgements Air Resources Board staff extends its appreciation to representatives of the Port of Oakland, Environ Corporation, and the Bay Area Air Quality Management District for providing assistance with preparation of the emissions inventory data and spatial allocation of emissions. The staff of the Air Resources Board has prepared this report.(More)
Interestingness measures stand as proxy for " real human interest , " but their effectiveness is rarely studied empirically due to the difficulty of obtaining ground-truth data. We propose a method based on learning-to-rank algorithms that enables pairwise rankings collected from domain community members to be used to learn a domain-specific measure. We(More)
This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice deficient in LTalpha (LTalpha-/-)(More)
Archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) is a safe mucosal adjuvant that elicits long lasting and memory boostable mucosal and systemic immune responses to model antigens such as ovalbumin. In this study, we evaluated the potential of the AMVAD system for eliciting protective immunity against mucosal bacterial infections, using a mouse(More)
CD8+ T-cells are involved in controlling HIV-1 infection by eliminating infected cells and secreting soluble factors that inhibit viral replication. To investigate the mechanism and significance of infection of CD8+ T-cells by HIV-1 in vitro, we examined the susceptibility of these cells and their subsets to infection. CD8+ T-cells supported greater levels(More)