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Medical imaging has opened a new door into biomedical research. In order to study various diseases of the brain and detect their impact on brain structure, robust and user friendly image processing packages are required. These packages must be multi-faceted to distinguish variations in size, shape, volume, and the ability to detect longitudinal changes over(More)
The University of Iowa's Psychiatric Iowa Neuroimaging Consortium (PINC) has developed a program for mutual information registration of BRAINS2 [2] data using ITK [1] classes, called BRAINSFit. We have written a helper class, itk::MultiModal3DMutualRegistrationHelper to simplify implementation and testing of different transform representations and(More)
OBJECTIVES Previous studies have shown that high serum ceramides are associated with memory impairment and hippocampal volume loss, but have not examined dementia as an outcome. The aim of this study was to examine whether serum ceramides and sphingomyelins (SM) were associated with an increased risk of all-cause dementia and Alzheimer disease (AD). (More)
Acknowledgements Air Resources Board staff extends its appreciation to representatives of the Port of Oakland, Environ Corporation, and the Bay Area Air Quality Management District for providing assistance with preparation of the emissions inventory data and spatial allocation of emissions. The staff of the Air Resources Board has prepared this report.(More)
Interestingness measures stand as proxy for " real human interest , " but their effectiveness is rarely studied empirically due to the difficulty of obtaining ground-truth data. We propose a method based on learning-to-rank algorithms that enables pairwise rankings collected from domain community members to be used to learn a domain-specific measure. We(More)
This report has been prepared by the staff of the California Air Resources Board. Publication does not signify that the contents reflects the views and policies of the Air Resources Board, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. ACKNOWLEDGMENTS The ARB would like to acknowledge the assistance(More)
INTRODUCTION Older adults with a high number of chronic conditions and who live in environments that do not promote physical activity have great difficulty initiating and adhering to exercise programs. Novel lifestyle activity interventions that can effectively increase physical activity may address disparities in health in these populations. This study(More)
INTRODUCTION There is a substantial interest in identifying interventions that can protect and buffer older adults from atrophy in the cortex and particularly, the hippocampus, a region important to memory. We report the 2-year effects of a randomized controlled trial of an intergenerational social health promotion program on older men's and women's brain(More)
Boolean search is still the method of choice for many kinds of professional search, such as constructing systematic reviews in legal and medical fields. It is effective for fast, high-recall document classification. Its drawback is the difficulty in crafting a Boolean query that captures semantically relevant documents. Ambiguous search terms lead to the(More)