Greg Goodall

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The Antarctic nematode Panagrolaimus davidi has an ice-active protein that shows recrystallization inhibition but no thermal hysteresis. It belongs to a class of ice-active proteins found in a variety of freezing-tolerant organisms that display insignificant levels of thermal hysteresis in the context of the environmental temperatures to which they are(More)
The pattern of ice formation during the freezing of Panagrolaimus davidi, an Antarctic nematode that can survive intracellular ice formation, was visualised using a freeze substitution technique and transmission electron microscopy. Nematodes plunged directly into liquid nitrogen had small ice crystals throughout their tissues, including nuclei and(More)
The manipulation of a single-stranded RNA target by forming different RNA/antisense hybrids demonstrates the possibility of cleaving the RNA strand within duplexes. This was achieved using the sequence composition of the antisense oligonucleotide, an approach that results in various bulges [unpaired base(s)] in the RNA target, which is then cleavable at(More)
The ability of the Antarctic nematode Panagrolaimus davidi to survive a short-term freezing stress depended upon the rate of freezing of its surroundings, measured as the duration of the sample exotherm. The freezing rate increased as the sample volume and freezing temperature decreased and resulted in fewer nematodes surviving. This appears to be due to(More)
We have recently shown that although pre-mRNA splicing in plants shares some features in common with splicing in vertebrates, there are some crucial differences. In plants there is a requirement for a general enrichment for A+U within the intron and there is no requirement for a 3 ' polypyrimidine tract (Goodall and Filipowicz, 1989). We suspect that the(More)
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