Mice with targeted deletion of fibrinogen-like protein 2 (fgl2) spontaneously developed autoimmune glomerulonephritis with increasing age, as did wild-type recipients reconstituted with fgl2-/- bone marrow. These data implicate FGL2 as an important immunoregulatory molecule and led us to identify the underlying mechanisms. Deficiency of FGL2, produced by… (More)
The purpose of this study was to define the role of secretory phospholipase A2 (sPLA2), calcium-independent PLA2, and cytosolic PLA2 (cPLA2) in arachidonic acid (AA) release from fMLP-stimulated human neutrophils. While fMLP induced the release of extracellular sPLA2 activity and AA, 70% of sPLA2 activity remained associated with the cell. Treatment with… (More)
There has been a sizeable investment in the development of large-scale data and appropriate infrastructures in the physical and biological sciences and increasingly in the social sciences and humanities. Concerns about data sustainability have attracted a great deal of attention as research project data collection represents a significant investment, and… (More)
This paper describes and explains the shift in the database industry's treatment of downloading as an unwanted byproduct of new technology to a product feature in terms of shifts in ―use-regimes,‖ or changes to market practices, legal rules, user expectations and technology-based tools that shape the use of intellectual and cultural property. In the early… (More)
The intertwining of the Internet with private-market production and consumption in the US so far has been told only from an "internalist" perspective, largely by the professional business press and mostly about a few ongoing examples of online business success, especially Amazon.com and Google.