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Cholecystokinin-tetrapeptide (CCK-4) and placebo were injected to 11 panic disorder patients. CCK-4 induced a panic attack identical to spontaneous panic attacks in all patients; placebo did not induce any attacks. The role of CCK-4 in anxiety disorders is discussed.
OBJECTIVE To compare the change in severity of depressive symptoms and occurrence of side effects in primary care patients treated with St John's wort (SJW) and sertraline. DESIGN Double-blind, randomized 12-week trial. SETTING Community-based offices of 12 family physicians practising in greater Montreal, Que. PARTICIPANTS Eighty-seven men and women… (More)
A double-blind comparison of clonazepam and lorazepam was conducted in 24 patients with acute mania. Patients received either clonazepam or lorazepam alone for 14 days. Treatment with lorazepam produced marked improvement in symptomatology, while treatment with clonazepam failed to demonstrate a significant therapeutic effect. Sixty-one percent of patients… (More)
OBJECTIVE There is a projected shortage of psychiatrists in Canada in forthcoming years. This study assessed factors in medical school education that are associated with students selecting psychiatry first and matching as a discipline. METHOD The Canadian Organization of Undergraduate Psychiatry Educators (COUPE) conducted telephone interviews and sent… (More)
Pharmacotherapy and psychotherapy, separately or in combination, have been used successfully in the treatment of depression. Recent studies have compared the two modes of treatment and their combination with respect to relative efficacy and have found psychotherapy, alone or combined with medication, to be the preferential treatment approach for depressive… (More)