Greg A. Timblin

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Foxo1 is a critical, direct regulator of Rag (recombination activating gene) transcription during B cell development and is thus essential for the generation of a diverse repertoire of antigen receptors. Although Foxo1 regulation has been widely studied in many cell types, pathways regulating Foxo1 in B cells have not been fully elucidated. By screening a(More)
V(D)J recombination creates antibody light chain diversity by joining a Vκ gene segment with one of four Jκ segments. Two Jκ germline-transcript (GT) promoters control Vκ-Jκ joining, but the mechanisms that govern Jκ choice are unclear. Here, we show in gene-targeted mice that the proximal GT promoter helps targeting rearrangements to Jκ1 by preventing(More)
1621 Proper functioning of the adaptive immune system requires that lymphocytes express a diverse repertoire of antigen receptors. The genes encoding these receptors are generated by V(D)J recombination, a process by which various gene segments at the Ig or T cell receptor loci are joined together during development to create novel antigen receptor genes(More)
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