Grazielle Mecabo

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BACKGROUND Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the(More)
We read with great interest the recent review presented by de Souza Pacheco and Goncalves, 1 and we would like to briefly report our experience with Klotho (KL) single nucleotide poly-morphisms (SNPs) and sickle cell disease (SCD). SCD presents a phenotypic heterogeneity that has not been fully elucidated yet. Genetic modifiers and environmental effects may(More)
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