Grazielle Mecabo

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BACKGROUND Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to compare the frequency of haptoglobin genotypes and the(More)
Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. The use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA(More)
We read with great interest the recent review presented by de Souza Pacheco and Goncalves, 1 and we would like to briefly report our experience with Klotho (KL) single nucleotide poly-morphisms (SNPs) and sickle cell disease (SCD). SCD presents a phenotypic heterogeneity that has not been fully elucidated yet. Genetic modifiers and environmental effects may(More)
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