Graziella Thiriet

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Dopaminergic neuronal pathways arise from mesencephalic nuclei and project axons to the striatum, cortex, limbic system and hypothalamus. Through these pathways dopamine affects many physiological functions, such as the control of coordinated movement and hormone secretion. Here we have studied the physiological involvement of the dopamine D2 receptors in(More)
An unequal decrease in cholinergic activity has been evidenced in discrete brain areas in the growth hormone, thyroid-stimulating hormone and prolactin deficient Snell dwarf mouse. The effect of the mutation's pituitary deficit on central cholinergic mechanisms appears to be selective: Normally high cholinergic activity areas such as striatum, olfactory(More)
The expression of cholinergic neurotransmission in the developing spinal cord was followed with pre- and postsynaptic cholinergic markers and histoautoradiographic determinations of cholinergic receptors and ultrastructural studies. Two distinct steps in the development of cholinergic markers were evident. The first step of cholinergic expression occurs(More)
The location of cholinergic neurons was studied during the development of the chick embryo spinal cord. A comparison between choline acetyltransferase (ChAT) immunocytochemistry and acetylcholinesterase (AChE) histochemistry was performed. ChAT-positive neurons could be detected only from embryonic day 9 (E9) onwards by the FITC technique and from E12(More)
Dopamine and serotonin neurotransmission has been investigated in striatum and in the septohippocampal pathway of the locomotor activity and memory deficient Snell dwarf mouse. In striatum a sharp decrease in 3-MT levels with a concomitant decrease in DA turnover is indicative of a strong decrement in the functional activity of striatal dopaminergic(More)
The response of cholinergic markers to pre- or postsynaptic blockage was followed during development of the chick embryo spinal cord, to understand better the maturation sequence of the developing cholinergic synapse. It has been shown that the developing neurotransmitter system is able to react to pre- or postsynaptic disturbances by compensatory(More)
Our previous analyses of the functional maturation of cholinergic neurotransmission in the chick embryo spinal cord showed that 12 days of development represents a crucial stage in the maturation of cholinergic neurotransmission. Since supraspinal inputs are essential for the modulation of motoneuron activity in the embryo, we studied, using a(More)
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