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Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events.
OBJECTIVES We hypothesized that the expansion of unusual T lymphocytes, CD4+CD28null T cells, might represent a key pathogenetic mechanism of recurrent instability. BACKGROUND Clinical presentationExpand
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Adjusted indirect meta-analysis of aspirin plus warfarin at international normalized ratios 2 to 3 versus aspirin plus clopidogrel after acute coronary syndromes.
After acute coronary syndromes, the beneficial effect of aspirin plus clopidogrel (A+C) or aspirin plus dose-adjusted warfarin (A+W) compared with aspirin alone is well established. However, theseExpand
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Unusual CD4+CD28nullT Lymphocytes and Recurrence of Acute Coronary Events
Objectives We hypothesized that the expansion of unusual T lymphocytes, CD4+CD28nullT cells, might represent a key pathogenetic mechanism of recurrent instability. Background Clinical presentation ofExpand
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Novel anti-inflammatory effect of statins: reduction of CD4+CD28null T lymphocyte frequency in patients with unstable angina
Statins, inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, are potent inhibitors of cholesterol biosynthesis and have greatly improved the management of ischaemic heart disease. RecentExpand
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P Acute Coronary Syndromes Unusual CD 4 CD 28 null T Lymphocytes and Recurrence of Acute Coronary Events
Methods Peripheral blood T cells from 120 consecutive unstable angina (UA) patients were analyzed for the distribution of T-cell subsets by flow cytometry. Patients were subgrouped according to theExpand
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  • Open Access
Exercise stress echocardiography with tissue Doppler imaging in risk stratification of mild to moderate aortic stenosis
Background Patients with mild to moderate aortic stenosis (AS) seem to have a worse outcome than commonly expected. Early identification of subjects who may develop a rapid disease progression orExpand
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Re: early decrease in coagulation activity after myocardial infarction is associated with lower risk of new ischaemic events: observations from the ESTEEM trial.
We have carefully read the interesting article of Christersson et al. focusing on the pivotal issue of risk stratification and prognosis in patients recovering from an acute myocardial infarctionExpand
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Ximelagatran versus warfarin in the prevention of atrial fibrillation-related stroke: both sides of the story.
To the Editor: We have carefully read the interesting article by Akins et al1 focusing on a pivotal issue in the prevention of atrial fibrillation-related stroke. The authors pooled the data fromExpand
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  • Open Access
The hurdles of warfarin and the hurdles of clinical practice.
To the Editor: We have carefully read the interesting article by Hylek et al focusing on a pivotal issue in the prevention of atrial fibrillation–related stroke.1 The article explored the challengeExpand
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  • Open Access