Grayson H. Snyder

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Gene microarrays are becoming a key tool for the analysis of changes in gene expression in a variety of conditions. Use of microarrays to analyze drug responses has mainly been restricted to comparing treated versus untreated samples at a few time points. Such data do not permit the use of another important tool, pharmacokinetic/pharmacodynamic (PK/PD)(More)
Corticosteroids (CS) regulate many enzymes at both mRNA and protein levels. This study used microarrays to broadly assess regulation of various genes related to the greater urea cycle and employs pharmacokinetic/pharmacodynamic (PK/PD) modeling to quantitatively analyze and compare the temporal profiles of these genes during acute and chronic exposure to(More)
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