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The effects of cell type and culture condition on the procoagulant activity of human mesenchymal stromal cell-derived extracellular vesicles.
TLDR
The findings suggest that, like intact MSCs, source variability among EVs is an important factor when considering EVs for potential therapeutic purposes. Expand
Functional stability of the TEG 6s hemostasis analyzer under stress
TLDR
The TEG 6s provides several improvements over other coagulation analyzers: it is easier to use and robustly resilient against motion and temperature stresses, which suggest that it may be capable of deployment not only in the clinical laboratory but also to a variety of austere settings. Expand
Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice.
TLDR
The treatment of hMSCs with a sub-toxic dose of doxorubicin can overcome TRAIL resistance and be a potential novel therapy for TNBC metastasis treatment, and synergistic effects on targeting metastatic TNBC are suggested. Expand
A HA2-Fusion tag limits the endosomal release of its protein cargo despite causing endosomal lysis.
TLDR
Results show that E5 causes the retention of its fused protein inside endosomes even after lysis takes place, establishing that HA2 analogs might not be useful PTDs unless cleavable linkers are engineered between PTD and protein cargo. Expand
Cold storage of platelets in platelet additive solution: an in vitro comparison of two Food and Drug Administration–approved collection and storage systems
TLDR
This study compared the metabolic, functional, and activation status of PLTs collected on a Trima apheresis collection system and stored refrigerated in Isoplate (ISO) PAS to PLT collected on an Amicus collection systemand stored refrigerate in Intersol (INT) P AS. Expand
Optimizing whole blood storage: hemostatic function of 35‐day stored product in CPD, CP2D, and CPDA‐1 anticoagulants
TLDR
Hemostatic function of refrigerated WB stored for 35 days in anticoagulants citrate–phosphate‐dextrose‐adenosine (CPDA‐1), citrate‐phosphATE‐d Extrose (CPD), or citrate-phosphates‐double dextrose (CP2D) is examined. Expand
Hemostatic characteristics of thawed, pooled cryoprecipitate stored for 35 days at refrigerated and room temperatures
TLDR
Hemostatic characteristics of thawed cryoprecipitate stored up to 35 days at refrigerated and room temperatures were assessed. Expand
Proceedings of the 5th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2017
TLDR
This work aims to provide a clear picture of the unique challenges faced by surgeons using minimally invasive surgery to treat central giant cell granuloma, a common complication of massive organ prolapse preoperatively and which can be fatal without surgery. Expand
Volumetric control of whole blood collection in austere environments
TLDR
Two methods for simple, rapid control of collection bag volume are described: a length of material to constrict the bag, and folding/clamping the bag for speed and consistency in blood collection. Expand
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