• Publications
  • Influence
Antibiotic resistance is ancient
The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all casesExpand
  • 1,302
  • 42
  • PDF
Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse
The rich fossil record of equids has made them a model for evolutionary processes. Here we present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated toExpand
  • 532
  • 22
  • PDF
Fifty thousand years of Arctic vegetation and megafaunal diet
Although it is generally agreed that the Arctic flora is among the youngest and least diverse on Earth, the processes that shaped it are poorly understood. Here we present 50 thousand years (kyr) ofExpand
  • 315
  • 15
  • PDF
Out of America: Ancient DNA Evidence for a New World Origin of Late Quaternary Woolly Mammoths
Although the iconic mammoth of the Late Pleistocene, the woolly mammoth (Mammuthus primigenius), has traditionally been regarded as the end point of a single anagenetically evolving lineage, recentExpand
  • 117
  • 13
  • PDF
Species-specific responses of Late Quaternary megafauna to climate and humans
Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA,Expand
  • 349
  • 11
  • PDF
Timing and extent of plio-pleistocene glaciations in north-western canada and east-central alaska
Abstract North-western Canada and eastern Alaska are recognised as having one of the oldest known continental glacial records (Late Pliocene) preserved in stratigraphical sections. These include theExpand
  • 82
  • 11
Ancient DNA analyses exclude humans as the driving force behind late Pleistocene musk ox (Ovibos moschatus) population dynamics
The causes of the late Pleistocene megafaunal extinctions are poorly understood. Different lines of evidence point to climate change, the arrival of humans, or a combination of these events as theExpand
  • 161
  • 9
  • PDF
True single-molecule DNA sequencing of a pleistocene horse bone.
Second-generation sequencing platforms have revolutionized the field of ancient DNA, opening access to complete genomes of past individuals and extinct species. However, these platforms are dependentExpand
  • 113
  • 8
  • PDF
Late pleistocene chronology of glacial lake old crow and the north-west margin of the laurentide ice sheet
Late Pleistocene advances of the Laurentide Ice Sheet in the northern Cordillera diverted westward the regional preglacial arctic drainage of the Porcupine River, northern Yukon, Canada. GlacialExpand
  • 40
  • 7
Bison phylogeography constrains dispersal and viability of the Ice Free Corridor in western Canada
The Ice Free Corridor has been invoked as a route for Pleistocene human and animal dispersals between eastern Beringia and more southerly areas of North America. Despite the significance of theExpand
  • 73
  • 5
  • PDF