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Dopamine in schizophrenia: a review and reconceptualization.
OBJECTIVE The initial hypothesis that schizophrenia is a manifestation of hyperdopaminergia has recently been faulted. However, several new findings suggest that abnormal, although not necessarilyExpand
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An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder.
Ninety patients with schizophrenia or schizoaffective disorder according to DSM-III-R criteria participated in this double-blind, exploratory, dose-ranging trial. After a single-blind washout periodExpand
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Clinical and Sensorimotor Gating Effects of Ketamine in Normals
The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia. Sensory gating, as measured by prepulseExpand
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Autonomic responses to stress in Vietnam combat veterans with posttraumatic stress disorder
This study tested the hypothesis that combat veterans with posttraumatic stress disorder (PTSD) experience sympathetic nervous system activation in response to war-related laboratory stimuli.Expand
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Clozapine in China: a review and preview of US/PRC collaboration
During the course of an official US-People's Republic of China (PRC) Joint Health Agreement, a number of Chinese investigators have come to the intramural program of the NIMH for varying periods ofExpand
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The Shanghai 800: prevalence of tardive dyskinesia in a Chinese psychiatric hospital.
The authors found that 73 (8.4%) of 866 patients with chronic schizophrenia in the Shanghai Psychiatric Hospital who had been treated with neuroleptics had tardive dyskinesia. This low prevalenceExpand
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Prospective study of noise exposure during pregnancy on birth weight.
To examine the effect of noise exposure during pregnancy on infant birth weight, a well-characterized cohort of 200 pregnant women in the first trimester participating in prenatal care clinics wasExpand
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Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
Transplantation of embryonic substantia nigra into the adult rat brain decreases the motor asymmetry that is produced by dopamine receptor supersensitivity after a unilateral lesion of the substantiaExpand
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