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Neuronal ceroid lipofuscinosis is a group of neurodegenerative disorders characterized by accumulation of lipofuscin and/or ceroid within the tissues of the body. These entities are manifest by visual, intellectual, and motor deterioration as well as recurrent seizures. Computed tomography has been shown to demonstrate changes of cerebral atrophy in more(More)
We studied the normal and abnormal morphology of the corpus callosum in 450 midline sagittal magnetic resonance scans. Clinical information was required to differentiate acquired and congenital defects. Four forms of congenital anomalies were observed: focal attenuations, cysts, partial agenesis, and complete agenesis. Acquired changes resulted from(More)
In the course of examining 1,000 patients with various neurological complaints, 17 were found to have abnormalities in the region of the pineal gland. Fourteen had no hydrocephalus or symptoms referable to the region of the midbrain but a well-defined region of the high signal on T2 weighted images was demonstrated on magnetic resonance imaging. The other(More)
PURPOSE The purpose of this systematic review was to synthesize the available Level I and Level II literature on platelet-rich plasma (PRP) as a therapeutic intervention in the management of symptomatic knee osteoarthritis (OA). METHODS A systematic review of Medline, Embase, Cochrane Central Register of Controlled Trials, PubMed, and(More)
Five patients afflicted with subacute sclerosing panencephalitis were studied with computed tomography and magnetic resonance imaging. Computed tomography documented changes of nonspecific cerebral atrophy and low attenuation in the subcortical white matter. Magnetic resonance imaging revealed bilateral, symmetric, and diffuse abnormal increased signal in(More)
We have treated 15 children with end-stage renal disease (ESRD), renal osteodystrophy, and genu valgum in the last 22 years. In a retrospective review, we determined that periods of metabolic instability, best characterized as an alkaline phosphatase of 500 U for at least 10 months, were associated with progression of deformity. Histomorphometric bone(More)
Two patients with uncontrollable complex partial seizures had normal findings on pre- and postinfusion computed tomography scans. Magnetic resonance imaging demonstrated, in both patients, a lesion in the temporal lobe suggestive of mesial temporal sclerosis. One patient underwent temporal lobectomy, and the radiologic diagnosis was verified. In patients(More)
Intracranial convolutional or gyriform calcification simulating Sturge-Weber syndrome has been described in association with bacterial and viral intracranial infection as well as irradiation and intrathecal methotrexate for central nervous system leukemia. Reported is a case of gyriform calcification caused by chemical meningitis secondary to subarachnoid(More)