Grant H Skrepnek

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OBJECTIVE This trial was conducted to compare the efficacy and tolerability of a fixed dose of escitalopram 10 mg/day with sertraline optimally dosed within its recommended dose range (50-200 mg/day) for the treatment of major depressive disorder. METHODS In this multicenter trial, depressed patients (DSM-IV defined; baseline Montgomery-Asberg Depression(More)
OBJECTIVES To investigate prescribers' rationales for overriding drug-drug interaction (DDI) alerts and to determine whether these reasons were helpful to pharmacists as a part of prescription order verification. STUDY DESIGN An observational retrospective database analysis was conducted using override reasons derived from a computerized system at 6(More)
BACKGROUND Given the high prevalence of medication use in the US, the risk of drug-drug interactions (DDIs) and potential for patient harm is of concern. Despite the rise in technologies to identify potential DDIs, the ability of physicians and other prescribers to recognize potential DDIs is essential to reduce their occurrence. The objectives of this(More)
OBJECTIVE To construct a cost-utility model comparing escitalopram with sertraline in the treatment of major depressive disorders. METHODS A decision analytic model was created to compare the cost-utility of these two antidepressants from the perspective of a managed-care organization. The model was designed to compare 10-20 mg/day of escitalopram to(More)
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of hospitalizations in the United States and the major cost driver of COPD. This study determined the national inpatient burden of AECOPD and assessed the association of co-morbidities and hospital characteristics with inpatient costs and mortality. Discharge records(More)
BACKGROUND Drug-drug interactions (DDIs) are preventable medical errors, yet exposure to DDIs continues despite systems that are designed to prevent such exposures. The purpose of this study was to examine pharmacy characteristics that may be associated with dispensed potential DDIs. METHODS This study combined survey data from community pharmacies in 18(More)
OBJECTIVES To demonstrate a curriculum mapping technique and its use in program evaluation and assessment, as well as to provide specific recommendations for potential uses in pharmacy education. METHODS This study employed a descriptive cross-sectional study design based on a learning outcomes document and several existing student and curricular data(More)
OBJECTIVE The aim of this paper is to provide health care decision makers with a conceptual foundation for regression analysis by describing the principles of correlation, regression, and residual assessment. SUMMARY Researchers are often faced with the need to describe quantitatively the relationships between outcomes and predictors , with the objective(More)
Ovarian cancer is the fourth leading cause of cancer death among women in the United States. First-line chemotherapy offered to patients with ovarian cancer generally consists of an intravenous (IV) platinum plus taxane regimen and has remained virtually unchanged for the past 10 years. A number of recently completed phase III randomized trials in the(More)
OBJECTIVE To assess 1-year persistence and adherence with monotherapy using the most commonly dispensed individual agent in 4 antihypertensive drug classes: hydrochlorothiazide (HCTZ), amlodipine, lisinopril, or valsartan. DESIGN Retrospective, longitudinal analysis of initial prescriptions during 2001 to 2002 from a nationwide administrative claims(More)