Grant F A Benfield

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We have evaluated the orally active anthracycline idarubicin at a dose of 40 mg/m2 in divided doses over 24 hours in 21 previously untreated patients with extensive-stage small cell carcinoma of the lung (SCCL). Subsequent iv therapy was cyclophosphamide (1000 mg/m2), vincristine (1 mg/m2), and etoposide (120 mg/m2 iv on Day 1 and 250 mg/m2 orally in(More)
1 Twelve-week courses of oxprenolol and methyldopa were administered in a randomised, double-blind cross over study to ten insulin dependent hypertensive diabetics. 2 Prior to treatment, and at the end of each period of drug administration, fasting levels of high density lipoprotein, triglycerides, free fatty acids and cholesterol were measured. 3 Neither(More)
Occupational asthma due to the pyrolysis products of polyvinyl chloride (PVC) produced by shrink wrapping processes has previously been reported. The first case of occupational asthma in a shrink wrap worker using a different plastic, polyethylene, is reported; the association was confirmed by specific bronchial provocation testing.
A 59-year-old housewife, a non-smoker, had been maintained for some years with salbutamol and beclomethasone aerosols for her asthma. She was admitted to hospital with a seven-day history of progressively worsening dyspnoea associated with marked wheezing, unrelieved by more frequent use of her inhalers, the addition of prednisolone (40 mg daily), and a(More)
The clinical features of patients admitted with acute severe asthma which discriminated between groups who respond rapidly to treatment (attain their maximum PEFR within 3 days), slowly (maximum PEFR after 7 days) and at an intermediate rate (maximum PEFR 3-7 days), have been previously identified in this unit. These included age, atopy, duration of the(More)
One hundred and twenty-three patients with empyema thoracis presenting between 1968 and 1978 were studied. The predominant cause was pneumonia, with thoracic and gastrooesophageal surgery as the other important predisposing factors. 99 patients had received antibiotics before hospital admission and organisms were isolated from the empyema of 62 of these(More)