Grant F A Benfield

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Occupational asthma due to the pyrolysis products of polyvinyl chloride (PVC) produced by shrink wrapping processes has previously been reported. The first case of occupational asthma in a shrink wrap worker using a different plastic, polyethylene, is reported; the association was confirmed by specific bronchial provocation testing.
One hundred and twenty-three patients with empyema thoracis presenting between 1968 and 1978 were studied. The predominant cause was pneumonia, with thoracic and gastrooesophageal surgery as the other important predisposing factors. 99 patients had received antibiotics before hospital admission and organisms were isolated from the empyema of 62 of these(More)
1 Twelve-week courses of oxprenolol and methyldopa were administered in a randomised, double-blind cross over study to ten insulin dependent hypertensive diabetics. 2 Prior to treatment, and at the end of each period of drug administration, fasting levels of high density lipoprotein, triglycerides, free fatty acids and cholesterol were measured. 3 Neither(More)
We have evaluated the orally active anthracycline idarubicin at a dose of 40 mg/m2 in divided doses over 24 hours in 21 previously untreated patients with extensive-stage small cell carcinoma of the lung (SCCL). Subsequent iv therapy was cyclophosphamide (1000 mg/m2), vincristine (1 mg/m2), and etoposide (120 mg/m2 iv on Day 1 and 250 mg/m2 orally in(More)
To compare treatment success of large- and small-bore chest drains in the treatment of spontaneous pneumothoraces the case-notes were reviewed of those admitted to our hospital with a total of 73 pneumothoraces and who were treated by trainee doctors of varying experience. Both a large- and a small-bore intercostal tube drain system were in use during the(More)
Eight patients with local Stage II (T2N1) and III (T3N0, T3N1, T2N2) small cell lung cancer received combination chemotherapy prior to elective surgery to assess the effectiveness of such a regimen in improving operability, preventing local relapse and extending survival. The regimen was well tolerated and prevented local relapse. However, the median time(More)
The clinical features of patients admitted with acute severe asthma which discriminated between groups who respond rapidly to treatment (attain their maximum PEFR within 3 days), slowly (maximum PEFR after 7 days) and at an intermediate rate (maximum PEFR 3-7 days), have been previously identified in this unit. These included age, atopy, duration of the(More)