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- Graham S. Timmins, Vojo Deretic
- Molecular microbiology
- 2006
For decades after its introduction, the mechanisms of action of the front-line antituberculosis therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that peroxidative… (More)
- Sharon S. Master, Silvana K. Rampini, +6 authors Vojo Deretic
- Cell host & microbe
- 2008
Mycobacterium tuberculosis (Mtb) parasitizes host macrophages and subverts host innate and adaptive immunity. Several cytokines elicited by Mtb are mediators of mycobacterial clearance or are… (More)
- Eliseo F Castillo, Alexander Dekonenko, +11 authors Vojo Deretic
- Proceedings of the National Academy of Sciences…
- 2012
Autophagy is a cell biological pathway affecting immune responses. In vitro, autophagy acts as a cell-autonomous defense against Mycobacterium tuberculosis, but its role in vivo is unknown. Here we… (More)
- John P. Collier, Barbara H Currier, +4 authors Robin L. Brewer
- Clinical orthopaedics and related research
- 2003
Cross-linked polyethylenes are being marketed by orthopaedic manufacturers to address the problem of osteolysis caused by polyethylene particulate wear debris. Wear testing of these cross-linked… (More)
- Leslie P Lund, Graham S. Timmins
- Pharmacology & therapeutics
- 2007
Although sunlight is known to cause melanoma, there has been considerable controversy as to the importance of short (UVB) and long (UVA) ultraviolet (UV) wavelengths in causing melanoma, leading to… (More)
- Pamela R Hall, Bradley O. Elmore, +11 authors Hattie Gresham
- PLoS pathogens
- 2013
Staphylococcus aureus contains an autoinducing quorum-sensing system encoded within the agr operon that coordinates expression of virulence genes required for invasive infection. Allelic variation… (More)
- Sharon S. Master, Burkhard Springer, Peter T. Sander, Erik C Böttger, Vojo Deretic, Graham S. Timmins
- Microbiology
- 2002
The Mycobacterium tuberculosis ahpC gene, encoding the mycobacterial orthologue of alkylhydroperoxide reductase, undergoes an unusual regulatory cycle. The levels of AhpC alternate between stages of… (More)
- Barbara H. Miller, Rutilio A. Fratti, +5 authors Vojo Deretic
- Infection and immunity
- 2004
Inducible nitric oxide synthase (iNOS) is a cytoplasmic protein responsible for the generation of nitric oxide (NO. ) in macrophages. In this work, we hypothesized that the intracellular localization… (More)
- Simon R. Wood, Marianne Berwick, Ronald Douglas Ley, Ronald B. Walter, Richard B. Setlow, Graham S. Timmins
- Proceedings of the National Academy of Sciences…
- 2006
Controversy continues both as to which wavelengths of sunlight cause melanoma and the mechanisms by which these different wavelengths act. Direct absorption of UVB by DNA is central in albino animal… (More)
- Shimin Liu, Honglian Shi, Wenlan Liu, Takamitsu Furuichi, Graham S. Timmins, Ke Jian Liu
- Journal of cerebral blood flow and metabolism…
- 2004
Stroke causes heterogeneous changes in tissue oxygenation, with a region of decreased blood flow, the penumbra, surrounding a severely damaged ischemic core. Treatment of acute ischemic stroke aims… (More)