We show that the scale of the inflationary potential may be the electroweak scale or even lower, while still generating an acceptable spectrum of primordial density perturbations. Thermal effects readily lead to the initial conditions necessary for low scale inflation to occur, and even the moduli problem can be evaded if there is such an inflationary… (More)
Molecular markers that predict responses to particular therapies are invaluable for optimization of patient treatment. The TRYPHAENA study showed that pertuzumab and trastuzumab with chemotherapy was an efficacious and tolerable combination for patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer in the neoadjuvant setting.… (More)
Although the incidence of cancer increases with age, older patients are under-represented in cancer treatment trials, resulting in limited data availability in this patient population. Here we present results from pre-defined subgroup analyses conducted by age group (<65 vs ≥ 65 years) from a randomized, double-blind, placebo-controlled phase III trial in… (More)
This paper is developed from one section of the course which deals with the problem of how a mediator can develop the necessary level of trust when communicating online and overcome what may at first sight appear as barriers to delivering online the benefits of mediation.