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- Graham P Pawelec, A. H. Akbar, Calogero Caruso, Rafael Sabido Solana, Beatrix Grubeck-Loebenstein, Anders Wikby
- Immunological reviews
- 2005
Morbidity and mortality due to infectious disease is greater in the elderly than in the young, at least partly because of age-associated decreased immune competence, which renders individuals more… (More)
- Steffen Walter, Toni Weinschenk, +36 authors Harpreet Singh-Jasuja
- Nature Medicine
- 2012
IMA901 is the first therapeutic vaccine for renal cell cancer (RCC) consisting of multiple tumor-associated peptides (TUMAPs) confirmed to be naturally presented in human cancer tissue. We treated a… (More)
- Graham P Pawelec, Evelyna Derhovanessian, Anis Larbi, Jan Strindhall, Anders Wikby
- Reviews in medical virology
- 2009
'Immunosenescence' is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. Primarily anecdotal evidence implies that… (More)
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also… (More)
- Anders Wikby, Frederick G Ferguson, +7 authors B Johansson
- The journals of gerontology. Series A, Biological…
- 2005
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment… (More)
- P. C. Calder, Namanjeet Ahluwalia, +14 authors Jun-jun Zhao
- The British journal of nutrition
- 2013
To monitor inflammation in a meaningful way, the markers used must be valid: they must reflect the inflammatory process under study and they must be predictive of future health status. In 2009, the… (More)
- Graham P Pawelec, Evelyna Derhovanessian
- Virus research
- 2011
"Immune senescence" is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so far. While all components of innate and adaptive immunity are… (More)
- Monica Uddin, Allison E Aiello, +5 authors Sandro Galea
- Proceedings of the National Academy of Sciences…
- 2010
The biologic underpinnings of posttraumatic stress disorder (PTSD) have not been fully elucidated. Previous work suggests that alterations in the immune system are characteristic of the disorder.… (More)
- Jan Strindhall, B. O. Nilsson, +4 authors Anders Wikby
- Experimental Gerontology
- 2007
In the present NONA immune longitudinal study, we investigate the previously identified Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus… (More)
- Tamás Fülöp, Anis Larbi, Graham P Pawelec
- Front. Immunol.
- 2013
Aging is associated with a dysregulation of the immune response, loosely termed "immunosenescence." Each part of the immune system is influenced to some extent by the aging process. However, adaptive… (More)