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Journals and Conferences
The rising cost of pharmaceutical expenditures in many European countries is of concern to governments required to make effective use of health care budgets. Taking a broad perspective that encompasses institutional, political and supranational aspects of pharmaceutical regulation, this book examines approaches used to manage pharmaceutical expenditure… (More)
Immunoglobulin E (IgE) plays a critical role in both resistance to parasitic infection and allergy to environmental antigens. The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. In this report, we show that New Zealand black (NZB) mice express a variant… (More)
This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 kD-hGH, and two peptides made up of portions of 22 kD-hGH. The two pituitary peptides (hGH(1-43) and hGH(44-191)) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The… (More)
The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). Although much is known about the contribution of the lpr Fas mutation to B cell tolerance breakdown, the role of the genetic background of the MRL strain itself is less well explored. In this study, we use the MD4 anti-hen egg lysozyme… (More)
Genetics is slowly explaining variations in drug response, but applying this knowledge depends on implementation of a host of policies that provide long-term support to the field, from translational research and regulation to professional education.
BACKGROUND In recent decades, extensive resources have been invested to develop cellular, molecular and genomic technologies with clinical applications that span the continuum of cancer care. METHODS In December 2006, the National Cancer Institute sponsored the first workshop to uniquely examine the state of health services research on cancer-related… (More)
Following exposure of cultured human synovial cells to human recombinant interleukin 1α (IL-1α), we demonstrate the appearance of factors in the supernatant which stimulate human polymorphonuclear leukocyte (PMN) locomotion and elevate intracellular free calcium ([Ca++] i ). The production of these factors can be abolished by actinomycin D or dexamethasone… (More)
The chemistry, biosynthesis and general pharmacology of leukotrienes C4 and D4 are reviewed, with emphasis on the cardiovascular and smooth muscle effects of these agents. Pathways controlling the formation of the leukotrienes are considered together with their possible pathophysiological roles.
There has been considerable scientific, corporate and policy interest in the more effective use of genetics in both drug development and delivery. Pharmacogenetics — the study of the relationship between an individual's genetic makeup and response to medicinal drugs — has attracted global interest, but will it live up to its promise? Looking beyond the hype… (More)
Gold salts, auranofin (AF), aurothiomalate (ATM) and aurothioglucose (ATG) displayed immunosuppressive action in a series ofin vitro assays which mimic the cell-cell interactions thought to occur in rheumatoid arthritis. The gold salts inhibited phytohaemagglutinin (PHA)-induced thymidine incorporation and γ-IF production by peripheral blood mononuclear… (More)