Graham M Coombes

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Postmenopausal women with established vertebral osteoporosis were studied for 2 years to determine the terminal elimination half-life and the duration of response to treatment with intravenous alendronate (30 mg) given over 4 days. The urinary excretion of alendronate followed a multiexponential decline. Approximately 50% of the total dose was excreted over(More)
We compared the effects of three different regimens of intravenous clodronate in a retrospective study of 60 patients with Paget disease. A total dose of 1500 mg of clodronate was given as 300 mg for 5 consecutive days (n = 20), 1500 mg as a single infusion (n = 20), or 300 mg as a single infusion for 5 consecutive months (n = 20). The response to treatment(More)
We studied retrospectively 51 patients with Paget's disease of bone treated with oral clodronate, 1600 mg daily given for 1 (n = 23), 3 (n = 13), or 6 months (n = 15), to compare the effect of a variable length of treatment on the response rate to treatment and the duration of disease suppression. Activity of alkaline phosphatase and urinary hydroxyproline(More)
The accuracy of 2 successive models of a portable (2.5 kg.) ultrasound unit in determining residual urine volumes in 100 patients was assessed. Ultrasound measurements were compared to post-scan bladder volumes obtained by catheterization and fluoroscopic screening in the same patients. The first ultrasound unit (group 1, 50 patients) showed correlation(More)
BACKGROUND Australian bladder cancer patients especially women are thought to have worse outcomes when compared to the other international series. The objective of this study was to assess the pathological pattern of primary bladder cancer at the time of radical cystectomy as well as assessing the quality of resection in New South Wales. METHOD Pathology(More)
We studied four treatment regimens of oral alendronate in 60 patients with active Paget's disease. Two groups received an oral daily dose of either 40 or 80 mg of alendronate for 3 months, followed by placebo for a further 3 months: the other two groups received treatment with 40 or 80 mg per day for 6 months. Activity of alkaline phosphatase and urinary(More)
BACKGROUND The aim of this study was to determine the incidence and tumour characteristics of incidental prostatic cancer in Australian men with primary bladder cancer undergoing radical cystoprostatectomy (RCP). METHOD Cystoprostatectomy specimens were reviewed for a 10-year period from a leading pathology centre in the state of New South Wales,(More)
Endometriosis is a common condition that affects as many as 10% to 20% of women of reproductive age. Because of the subtle clinical signs and symptoms and limitations of imaging methods, the diagnosis is frequently delayed or missed, with serious consequences including hypertension, hydronephrosis, and loss of kidney function. We present an unusual case of(More)
The accuracy of two portable handheld bladder scanners was assessed and compared to urethral catheterization. Two versions of the BladderScan BVI 2500 were used. Fifty patients were scanned with the two-step BVI 2500 device, and the second 50 were studied with a newer version, the one-step BVI 2500+, 5 minutes prior to catheterization. Postcatheterization(More)