Graham Klyne

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Scientific innovation depends on finding, integrating, and re-using the products of previous research. Here we explore how recent developments in Web technology, particularly those related to the publication of data and metadata, might assist that process by providing semantic enhancements to journal articles within the mainstream process of scholarly(More)
A workflow-centric research object bundles a workflow, the provenance of the results obtained by its enactment, other digital objects that are relevant for the experiment (papers, datasets, etc.), and annotations that semantically describe all these objects. In this paper, we propose a model to specify workflow-centric research objects, and show how the(More)
MOTIVATION Integrating heterogeneous data across distributed sources is a major requirement for in silico bioinformatics supporting translational research. For example, genome-scale data on patterns of gene expression in the fruit fly Drosophila melanogaster are widely used in functional genomic studies in many organisms to inform candidate gene selection(More)
FlyTED, the Drosophila Testis Gene Expression Database, is a biological research database for gene expression images from the testis of the fruit fly Drosophila melanogaster. It currently contains 2762 mRNA in situ hybridization images and ancillary metadata revealing the patterns of gene expression of 817 Drosophila genes in testes of wild type flies and(More)
CLAROS (Classical Art Research Online Services; is an international interdisciplinary research initiative led by the University of Oxford (Humanities and Mathematics and Physical Sciences), hosted by the Oxford e-Research Centre (OeRC,, and inspired by the Beazley Archive ( participating in EU R&D(More)
Scientific workflows are a popular mechanism for specifying and automating data-driven in silico experiments. A significant aspect of their value lies in their potential to be reused. Once shared, workflows become useful building blocks that can be combined or modified for developing new experiments. However, previous studies have shown that storing(More)
To created a linked data web of heterogeneous biological data resources, we need not only to define and create the alignment between related data resources but also to express the knowledge about why data items from different sources are linked with each other and how each data link has evolved, so that scientists can trust the data links provided by the(More)
BACKGROUND One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment,(More)
Research in life sciences is increasingly being conducted in a digital and online environment. In particular, life scientists have been pioneers in embracing new computational tools to conduct their investigations. To support the sharing of digital objects produced during such research investigations, we have witnessed in the last few years the emergence of(More)
This paper describes some experimental work for modelling complex systems with RDF. Basic RDF represents information at a very fine level of granularity. The thrust of this work is to build higher-level constructs in RDF that allow complex systems to be modelled incrementally, without necessarily having full knowledge of the detailed ontological structure(More)