Graham J. Walkden

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INTRODUCTION Obesity confers a survival advantage in the critically ill and in patients undergoing cardiac surgery. We explored whether an obesogenic high fat diet could confer protection against post cardiopulmonary bypass (CPB) acute kidney injury (AKI) in a swine model. METHODS In this study, 28 anaesthetised adult female Landrace White swine (55 to 70(More)
To evaluate the effect of aprotinin withdrawal in 2008 on patient outcomes, to assess the likely risks and benefits of its re-introduction, and to consider the relevance of existing evidence from clinical trials to ‘real-world’ practice. We performed a nested case–control study of two cohorts undergoing adult cardiac surgery in a single tertiary centre. The(More)
BACKGROUND Allogeneic erythrocyte transfusion in cardiac surgical patients is associated with a fourfold increase in pulmonary complications. Our understanding of the processes underlying these observations is poor and there is no experimental model of transfusion-related acute lung injury that shows homology to cardiac surgical patients. Our objective was(More)
Dear Editor, We appreciate the interest that DeSantis and Lazaridis [1] have expressed in our study [2]. We are indeed in agreement that the residual confounding which is introduced by covariate imbalance could have introduced bias into our estimates of the effects of aprotinin withdrawal on clinical outcomes. Although we provide readers with t-tests, we(More)
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