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This work describes the development of a model of cerebral atrophic changes associated with the progression of Alzheimer's disease (AD). Linear registration, region-of-interest analysis, and voxel-based morphometry methods have all been employed to elucidate the changes observed at discrete intervals during a disease process. In addition to describing the… (More)

- Andrew Janke, Huawei Zhao, Gary J Cowin, Graham J Galloway, David M Doddrell
- Magnetic resonance in medicine
- 2004

Spatial encoding in MR techniques is achieved by sampling the signal as a function of time in the presence of a magnetic field gradient. The gradients are assumed to generate a linear magnetic field gradient, and typical image reconstruction relies upon this approximation. However, high-speed gradients in the current generation of MRI scanners often… (More)

- Deming Wang, Jonathan B Chalk, Stephen E Rose, Greig de Zubicaray, Gary Cowin, Graham J Galloway +4 others
- Magnetic resonance imaging
- 2002

We present global and regional rates of brain atrophy measured on serially acquired T1-weighted brain MR images for a group of Alzheimer's disease (AD) patients and age-matched normal control (NC) subjects using the analysis procedure described in Part I. Three rates of brain atrophy: the rate of atrophy in the cerebrum, the rate of lateral ventricular… (More)

The recently proposed track-density imaging (TDI) technique was introduced as a means to achieve super-resolution using diffusion MRI. This technique is able to increase the spatial resolution of the reconstructed images beyond the acquired MRI resolution by incorporating information from whole-brain fibre-tracking results. It not only achieves… (More)

Digital Imaging Processing (DIP) requires data extraction and output from a visualization tool to be consistent. Data handling and transmission between the server and a user is a systematic process in service interpretation. The use of integrated medical services for management and viewing of imaging data in combination with a mobile visualization tool can… (More)

- G J Galloway, K Schleich, D M Witt, E Woolgar
- 1999

Motivated by recent interest in black holes whose asymptotic geometry approaches that of anti–de Sitter spacetime, we give a proof of topological censorship applicable to spacetimes with such asymptotic behavior. Employing a useful rephrasing of topological censorship as a property of homotopies of arbitrary loops, we then explore the consequences of… (More)

- G J Galloway, K Schleich, D M Witt, E Woolgar
- 2001

1 Abstract In [1] it was shown that (n + 1)-dimensional asymptotically anti-de-Sitter spacetimes obeying natural causality conditions exhibit topological censorship. We use this fact in this paper to derive in arbitrary dimension relations between the topology of the timelike boundary-at-infinity, I, and that of the spacetime interior to this boundary. We… (More)

A method for the acquisition of localized 2D shift-correlated spectra, based on the combination of the stimulated-echo volume-selection and gradient-enhanced COSY experiments, is described. The sequence can be modified to perform a number of localized experiments including HOHAHA and DQF-COSY. The method is demonstrated in vivo by presentation of localized… (More)

- G J Galloway, S Surya, E Woolgar
- 2002

We prove two theorems, announced in hep-th/0108170, for static spacetimes that solve Einstein's equation with negative cosmological constant. The first is a general structure theorem for spacetimes obeying a certain convexity condition near infinity , analogous to the structure theorems of Cheeger and Gromoll for manifolds of non-negative Ricci curvature.… (More)

- G J Galloway, S Surya, E Woolgar
- 2002

The stability of physical systems depends on the existence of a state of least energy, or ground state. In gravity, this is guaranteed by the positive energy theorem. The proof employs spinor structure and can fail for certain spacetime topologies, such as those arising in non-supersymmetric Kaluza-Klein compactifications, which can decay to arbitrarily… (More)