Graham Fuller

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The members of the mitogen-activated protein (MAP) kinase family -- p44/p42 MAP kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAP kinase (p38) are known to be important mediators of the physiological plasticity or neurotoxicity induced in the striatum by activation of ionotropic glutamate receptors. However, our knowledge of the class of glutamate(More)
The transcription factor NF-kappaB has been implicated in the synaptic plasticity and neurotoxicity mediated by ionotropic glutamate receptors in the striatum. However, the class of glutamate receptor and the intracellular pathways involved have not been determined. Kainate, but not AMPA or NMDA, was found to activate NF-kappaB in superfused slices of rat(More)
Synaptosomal membranes were prepared from bovine retinas to measure both high- and low-affinity binding of [(3)H]muscimol which is displaceable by ?-aminobutyric acid (GABA) under various buffering conditions using Tris-citrate (non-physiological) and Krebs-Ringer's bicarbonate (physiological) buffers. The maximum number of high- and low-affinity sites(More)
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