Graham Edward Fagg

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Anticonvulsant properties of CGP 37849 and CGP 39551, two novel phosphono-amino acids which are competitive NMDA receptor antagonists, were examined in rodents. At optimal pretreatment times CGP 37849 suppressed electroshock-induced seizures in mice and rats with ED50 s ranging from 8 to 22 mg/kg after oral administration, and 0.4 to 2.4 mg/kg after i. v.(More)
The effects of NMDA receptor antagonism on learning and memory were investigated using competitive (DL-2-amino-7-phosphonoheptanoate, AP7) and non-competitive (MK 801) blockers in three different learning tasks. Administration (i.p.) of drugs prior to training resulted in impaired learning performance in the place-navigation and dark-avoidance paradigms,(More)
The release of endogenous amino acids into the perfused central canal of the cat spinal cord in vivo was studied using a [3H]dansyl chloride assay procedure. Perfusion of 0.1 mM p-chloromercuriphenyl-sulphonate (pCMS), an uptake inhibitor, augmented the efflux of most amino acids studied. The large increases in glycine, glutamate and GABA efflux (9.9, 5.3(More)
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