Graham Dawson

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An immunoassay readout method based on surface-enhanced Raman scattering (SERS) is described. The method exploits the SERS-derived signal from reporter molecules that are coimmobilized with biospecific species on gold colloids. This concept is demonstrated in a dualanalyte sandwich assay, in which two different antibodies covalently bound to a solid(More)
The Research Outputs Database (ROD) has been used to investigate the effects of different input variables, including the numbers of funding bodies, on the impact of research papers in a biomedical subfield (gastroenterology). This was determined by the medium-term impact of the journals in which they were published. It was shown that, when account was taken(More)
The genetic linkage relationships of the human glycosphingolipid β-galactosidases were determined using human-mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside β-galactosidase activities in the presence of their mouse counterparts, which takes advantage of the(More)
An X-ray crystal structure of Kelch-like ECH-associated protein (Keap1) co-crystallised with (1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid (compound (S,R,S)-1 a) was obtained. This X-ray crystal structure provides breakthrough experimental evidence for the true(More)
Three forms of nano-trititanate (H(2)Ti(3)O(7) nanomaterial) were prepared by a hydrothermal method to replace nano-TiO(2) for sterilizing the environment. The bactericidal capabilities of these nano-trititanates were observed to be more significant compared to nano-TiO(2) both with and without exposure to UV light. For the future commercial applications of(More)
A liquid crystal stationary phase for open tubular capillary electrochromatograpy (OTCEC) is fabricated by etching a fused silica tube and then bonding 4,4'-cyanopentoxy biphenyl by a silanization/hydrosilation process. The versatility of this electrophoretic capillary is demonstrated by separations of proteins, peptides, basic pharmaceuticals and the(More)
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.
The adsorption properties of two nanomorphologies of trititanate, nanotubes (TiNT) and plates (TiNP), prepared by the hydrothermal reaction of concentrated NaOH with different phases of TiO2, were examined. It was found that the capacity for both morphologies towards methylene blue (MB), an ideal pollutant, was extremely high, with the TiNP having a(More)
Two sets of peptides, each having structurally similar amino acid sequences, have been investigated by capillary electrochromatography (CEC) using etched chemically modified capillaries as the separation medium. In comparison to gradient RP-HPLC, the resolving power of the described CEC methods has been found to be superior. A number of variables have been(More)