Graham Brown

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– Tumor/abnormality segmentation from magnetic resonance imagery (MRI) can play a significant role in cancer research and clinical practice. Although accurate tumor segmentation by radiologists is ideal, it is extremely tedious. Experience shows that for MRI database indexing purposes approximate segmentations can be adequate. In this paper, we propose a(More)
Globoid cell leukodystrophy (GLD) or Krabbe disease, is a fatal demyelinating disease attributed to mutations in the galactocerebrosidase (GALC) gene. Loss of function mutations in GALC result in accumulation of the glycolipid intermediate, galactosylsphingosine (psychosine). Due to the cytotoxicity of psychosine, it has been hypothesized that accumulated(More)
BACKGROUND Development of the secondary palate (SP) is a complex event and abnormalities during SP development can lead to cleft palate, one of the most common birth disorders. Matrix metalloproteinases (MMPs) are required for proper SP development, although a functional role for any one MMP in SP development remains unknown. MMP-25 may have a functional(More)
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