Graham A Heieis

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Type 2 immune responses are defined by the cytokines interleukin 4 (IL-4), IL-5 and IL-13 and the cellular and physiological changes that these cytokines induce, including IgE production, eosinophilia, mast cell degranulation, mucus secretion and smooth muscle contraction. Together these responses provide a "weep and sweep" reflex that is optimised to expel(More)
Many pathogenic bacteria including Staphylococcus aureus use iron-chelating siderophores to acquire iron. Iron uptake oxidoreductase (IruO), a flavin adenine dinucleotide (FAD)-containing nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase from S. aureus, functions as a reductase for IsdG and IsdI, two paralogous heme degrading enzymes.(More)
Die Empfindlichkeit eines neuartigen Verfahrens zur Messung der Knochendichte wurde durch Verlaufsuntersuchungen bestätigt. Nach Calcium-Fluor-Therapie nahm der durchschnittliche Schwächungskoeffizient der Spongiosa bereits im ersten Monat um 12% zu. 6 Monate nach Therapiebeginn konnte bei 8 von 10 Patienten die Erhöhung der Knochendichte in der Spongiosa(More)
Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that different intestinal DC subsets are involved(More)
We report our experience during the last 6 years with 20 patients fitted with prosthesis (19 patients with osseointegration of screw, 1 patient with primarily gluing method) for camouflage of congenital or acquired (trauma, tumor resection) defects of the ear, nose, or eye. Out of a total of 53 extra-oral implants fitted, 3 were lost in the orbital area due(More)
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