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OBJECTIVE Elucidating the role of aggregated beta-amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the development of therapeutic trials. The present study aims to assess this relationship. METHODS Brain magnetic resonance imaging and [(11)C]Pittsburgh compound B(More)
BACKGROUND Supported by compelling genetic data regarding early-onset familial Alzheimer disease (AD), the amyloid beta-peptide (Abeta)-centric theory holds that Abeta is involved in the pathogenesis of sporadic AD. Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) genes lead to increased Abeta levels before(More)
The relationship between β-amyloid deposition and memory deficits in early Alzheimer's disease is unresolved, as past studies show conflicting findings. The present study aims to determine the relative contribution of regional β-amyloid deposition, hippocampal atrophy and white matter integrity to episodic memory deficits in non-demented older individuals(More)
UNLABELLED PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy in staging tumors and potentially in monitoring treatment response. The aim of this study was to evaluate newly diagnosed primary brain tumors for the presence of hypoxia, as indicated by the uptake of 18F-fluoromisonidazole (18F-FMISO) and to examine the(More)
PURPOSE Humanized monoclonal antibody A33 (huA33) targets the A33 antigen which is expressed on 95% of colorectal cancers. A previous study has shown excellent tumor-targeting of iodine-131 labeled huA33 (131I-huA33). Therefore, we did a phase I dose escalation trial of 131I-huA33 radioimmunotherapy. EXPERIMENTAL DESIGNS Fifteen patients with pretreated(More)
Diagnosis, treatment planning and prognosis may be improved by combining functional data with anatomic location via PET/CT dual-modality image registration. The aim of this work is to reveal the spatial accuracy, reliability and speed of registration techniques used in GeminiTM PET/CT Imaging System, as a part of quality assurance program for clinical and(More)
Respiratory motion artifacts can be a significant factor that limits the PET image quality. To improve image quality, surveillance systems have been developed to track the movements of the subject during scanning. Gating techniques utilizing the tracking information, are able to compensate for subject motion, thereby improving lesion detection. In this(More)
The PET image quality can be degraded due to respiratory motion artifacts. To improve image quality, gating techniques utilizing the tracking information are able to compensate for respiratory motion. In this paper, we present a gating method that utilizes the geometric sensitivity feature of a 3D-PET scanner system operating in list event acquisition mode.(More)
PURPOSE CS-1008 (tigatuzumab; phase I/II), an antihuman death receptor 5 (DR5) agonist, induces apoptosis and has cytotoxic activity against human cancer cell lines. This study reports on the preclinical validation of (111)In-labeled anti-DR5 humanized antibody CS-1008 as a diagnostic tool to study the DR5 occupancy in patients with cancer and establish(More)
Background: DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to DR5. DS-8273a is currently being used in clinical Phase I trials. This study evaluated the molecular imaging of DR5 expression in vivo in mouse tumor models using SPECT/CT and(More)