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BACKGROUND Planning for the treatment of infection with the 2009 pandemic influenza A (H1N1) virus through health care systems in developed countries during winter in the Northern Hemisphere is hampered by a lack of information from similar health care systems. METHODS We conducted an inception-cohort study in all Australian and New Zealand intensive care(More)
INTRODUCTION Older age is associated with higher prevalence of chronic illness and functional impairment, contributing to an increased rate of hospitalization and admission to intensive care. The primary objective was to evaluate the rate, characteristics and outcomes of very old (age >or= 80 years) patients admitted to intensive care units (ICUs). (More)
OBJECTIVE To determine the effect on cardiac arrests and overall hospital mortality of an intensive care-based medical emergency team. DESIGN AND SETTING Prospective before-and-after trial in a tertiary referral hospital. PATIENTS Consecutive patients admitted to hospital during a 4-month "before" period (May-August 1999) (n = 21 090) and a 4-month(More)
OBJECTIVE To describe the development of a binational intensive care database. SETTING One hundred thirty-eight intensive care units (ICUs) in Australia and New Zealand. METHODS A structure was developed to enable ICUs to submit data for central and local analysis. Reports were developed to allow comparison with similar ICU types and against published(More)
OBJECTIVE To study the effect of early and continuous venovenous hemofiltration (CVVH) on the plasma concentrations of several humoral mediators of inflammation and subsequent organ dysfunction in septic patients. DESIGN Randomized, controlled trial. SETTING Intensive care unit of a tertiary hospital. PATIENTS Twenty-four patients with early septic(More)
OBJECTIVE To determine whether the introduction of an intensive care unit-based medical emergency team, responding to hospital-wide preset criteria of physiologic instability, would decrease the rate of predefined adverse outcomes in patients having major surgery. DESIGN Prospective, controlled before-and-after trial. SETTING University-affiliated(More)
INTRODUCTION Higher lactate concentrations within the normal reference range (relative hyperlactatemia) are not considered clinically significant. We tested the hypothesis that relative hyperlactatemia is independently associated with an increased risk of hospital death. METHODS This observational study examined a prospectively obtained intensive care(More)
INTRODUCTION Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such patients. METHODS We divided patients resuscitated from nontraumatic cardiac arrest from 125 intensive care units (ICUs) into three(More)
OBJECTIVE To determine whether mild or moderate hypoglycemia that occurs in critically ill patients is independently associated with an increased risk of death. PATIENTS AND METHODS Of patients admitted to 2 hospital intensive care units (ICUs) in Melbourne and Sydney, Australia, from January 1, 2000, to October 14, 2004, we analyzed all those who had at(More)
OBJECTIVE To compare the safety, availability, and long-term sequelae of percutaneous vs. surgical tracheostomy. DESIGN Prospective, randomized, controlled study. SETTING Combined medical/surgical intensive care unit in a tertiary referral hospital. PATIENTS Two hundred critically ill mechanically ventilated patients who required tracheostomy. (More)